Author

Michael B. Black

ORCID 0000-0002-7314-5441Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:benchmarking· 2 Organism:human· 2 Organism:rat· 2 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Rasim BarutcuiD· 4 shared Alina Y. Efremenko· 2 shared Melvin E. AnderseniD· 2 shared Patrick D. McMulleniD· 2 shared Andy NongiD· 1 shared Joshua HarrilliD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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4 shared papersPharmacology & Toxicology

A. Rasim BarutcuORCID

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4 papers

Recent·Most cited

Pharmacology & ToxicologyToxicology and Applied PharmacologyPeer-reviewedMay 11, 2024

Investigating the mode of action for wasting produced by tetrachlorodibenzo-p-dioxin (TCDD) in rats using transcriptomics: Evidence for roles of AHR and ARNT in circadian cycling

Melvin E. Andersen, A. Rasim Barutcu, Michael B. Black, Joshua Harrill

This study investigates TCDD-induced wasting in rats using transcriptomics, showing AHR and ARNT involvement in circadian disruption and metabolic gene downregulation at high doses.

5 citations

ratbulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintMar 2, 2024

Investigating the mode of action for liver toxicity and wasting-like responses produced by high dose exposures to longer chain perfluoroacid substances (PFAS) using high throughput transcriptomics

A. Rasim Barutcu, Michael B. Black, Melvin E. Andersen

This study identifies pathway perturbations in liver caused by PFAS exposure, showing longer-chain PFAS downregulate lipid and steroid metabolism genes, similar to TCDD, suggesting a common MOA involving PPAR inhibition.

5 citations

humanbulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintOct 20, 2023

Impact of gene selection criteria on transcriptomic ontology-based point of departure estimates

Michael B. Black, Alina Y. Efremenko, A. Rasim Barutcu, Patrick D. McMullen

The paper evaluates how gene selection criteria affect transcriptomic-based point of departure estimates in toxicology using rat kidney and liver data.

DOI 10.1101/2023.10.20.561869

ratbulk RNA-seq

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJul 26, 2023

Assessing the basal gene expression of cancer cell lines for in vitro transcriptomic toxicology screening

Michael B. Black, Alina Y. Efremenko, Patrick D. McMullen…·Andy Nong

The paper assesses the basal gene expression of cancer cell lines to determine their relevance to specific human tissues for in vitro toxicology screening.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky