María Gutièrrez‐Mecinas

The paper re-examines the expression and projection patterns of Tacr1 and Gpr83 in spinal projection neurons, finding greater overlap and VPL connectivity than previously reported.

The paper characterizes somatostatin-expressing neurons in the anterolateral system, showing their axonal projections and suggesting a role in the affective-motivational dimension of pain.

The paper uses single-nucleus RNA sequencing to identify five distinct classes of anterolateral system neurons in the adult mouse spinal cord and their laminar distribution.

This study shows that NPY-expressing inhibitory interneurons in the spinal dorsal horn reduce pain and itch behaviors, suggesting they are potential targets for treating pathological pain and itch.