Alexandra B. Firsova

The paper identifies a novel asthma-associated epithelial differentiation trajectory involving KRT14+ basal cells and hillock-like cells that contributes to airway inflammation and remodelling in childhood-onset asthma.

The paper identifies gene-expression gradients along the lung airway axis and shows FGFR-signaling establishes these gradients postnatally.

Spapros selects optimal probe sets for targeted spatial transcriptomics to improve cell type identification and spatial variation detection across multiple datasets.

The paper introduces RRST, a spatial transcriptomics workflow that improves mRNA recovery from low-quality fresh frozen samples, demonstrating its effectiveness across multiple tissue types.

The paper creates a comprehensive topographic atlas of early human lung development, identifying cell states, trajectories, and interactions to understand cell heterogeneity origins.

SCRINSHOT maps cell states in tissue sections at single-cell resolution, showing high correlation with scRNA-Seq data and enabling detailed spatial analysis of cell types.