Author
Bikash Mishra
Hospital for Special SurgeryORCID 0000-0002-7351-2096Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2024-2025 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 32 mutual co-author links6 papers
Recent·Most cited
- ImmunologybioRxivPreprint
Beyond Antagonism: IL-4 Exploits TNF signaling to Shape Its Gene Expression Signature in Monocytes and Macrophages.
Ruoxi Yuan, Chao Yang, Bikash Mishra…·Lionel B. Ivashkiv
The paper shows IL-4 enhances TNF-induced gene expression in monocytes/macrophages through epigenetic mechanisms, revealing cooperative crosstalk between antagonistic cytokines.
3 citations - ImmunologyeLifePeer-reviewed
Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ Macrophages
Upneet K. Sokhi, Ruoxi Yuan, Bikash Mishra…·Lionel B. Ivashkiv
This study identifies a PGE2-cAMP axis that opposes IFN-γ regulation of TNF responses in IL-1β+ macrophages in RA and ICI-arthritis, revealing a novel regulatory mechanism for inflammatory gene expression.
- ImmunologyNature ImmunologyPeer-reviewed
IL-10 Targets IRFs to Suppress IFN and Inflammatory Response Genes by Epigenetic Mechanisms
Bikash Mishra, Mahesh Bachu, Ruoxi Yuan…·Lionel B. Ivashkiv
This study identifies how IL-10 suppresses inflammatory gene expression by targeting IRF transcription factors and altering chromatin accessibility and histone marks in human monocytes.
- ImmunologybioRxivPreprint
Epigenetic Regulation of Inflammatory NF-κB Target Genes by IFN-γ via IRF1
Bikash Mishra, Claire K. Wingert, Mahesh Bachu, Lionel B. Ivashkiv
This study shows IFN-γ enhances TLR-induced inflammatory gene expression through IRF1, which is critical for synergistic activation of genes like IL6 and TNF in human monocytes.
2 citations - ImmunologyJournal of Orthopaedic Research®Peer-reviewed
Staphyloccocus aureus biofilm, in the absence of planktonic bacteria, produces factors that activate counterbalancing inflammatory and immune-suppressive genes in human monocytes
Richard D. Bell, E. Abrefi Cann, Bikash Mishra…·Lionel B. Ivashkiv
This study shows S. aureus biofilm produces soluble factors that activate inflammatory and immune-suppressive genes in human monocytes, suggesting a role for these factors in modulating immune responses in PJI.
5 citations