Richard D. Bell

This study shows that Langerhans cells regulate postnatal dermal lymphatic development, which in turn controls adult immune responses.

SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.

This paper introduces a deep learning model for automated joint space detection in micro-CT images of mouse paws, significantly improving segmentation accuracy compared to semi-automated methods.

The paper shows IL-4 enhances TNF-induced gene expression in monocytes/macrophages through epigenetic mechanisms, revealing cooperative crosstalk between antagonistic cytokines.

This study identifies a PGE2-cAMP axis that opposes IFN-γ regulation of TNF responses in IL-1β+ macrophages in RA and ICI-arthritis, revealing a novel regulatory mechanism for inflammatory gene expression.

This study identifies how IL-10 suppresses inflammatory gene expression by targeting IRF transcription factors and altering chromatin accessibility and histone marks in human monocytes.

This study shows S. aureus biofilm produces soluble factors that activate inflammatory and immune-suppressive genes in human monocytes, suggesting a role for these factors in modulating immune responses in PJI.