Trisomy 21 impairs synchronized activity and connectivity in developing human Down syndrome cortical excitatory neuron networks
Manuel Peter, Raquel Real, Alessio Strano…·Frederick J. Livesey
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University College LondonORCID 0000-0002-7364-6553Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Manuel Peter, Raquel Real, Alessio Strano…·Frederick J. Livesey
Lewis Evans, Alessio Strano, Eleanor J. Tuck…·Frederick J. Livesey
The paper identifies LRRK2-regulated pathways for extracellular tau uptake in human neurons using CRISPR screens, showing LRRK2's role in monomeric tau endocytosis.
Federica Marinaro, Moritz Haneklaus, Zhechun Zhang…·Frederick J. Livesey
The paper constructs a single-cell atlas of the frontal cortex in early-onset monogenic Alzheimer's disease to identify cellular and molecular changes in disease mechanisms.
Sebastian Cachero, Marina Gkantia, Alexander Shakeel Bates…·Gregory S.X.E. Jefferis
BAcTrace is a new genetically encoded tool for retrograde neuronal tracing validated in Drosophila olfactory circuits.