Dinah S. Singer

This study shows BRD4 inhibits Aurora B kinase activity during mitosis by binding to it, and JNK phosphorylates BRD4 to release it, allowing Aurora B activation.

This paper identifies CHMP5 as a nuclear factor that promotes T cell leukemia by enhancing BRD4-p300-dependent transcription at enhancers and super-enhancers.

This study shows that microglia-specific Brd4 knockout reduces T cell reactivation and EAE pathology by impairing microglia-T cell interactions and neuroinflammation.

This study shows that mutation of the CCAAT promoter element disrupts stable transgenerational epigenetic inheritance of MHC Class I gene expression across four generations.

This study shows BRD4 influences alternative splicing by interacting with splicing machinery during transcription elongation in thymocytes and T-ALL cells.