Laurent Chatel‐Chaix

This study identifies conserved interactions of NS4B with the UFMylation pathway across orthoflaviviruses, revealing a novel role for UFMylation in viral replication and suggesting it as a therapeutic target.

This study shows that ECM signals induce mitochondrial elongation and activity through actin polymerization and integrin signaling in mammospheres.

This study identifies ATL2 as critical for flavivirus replication by organizing viral replication organelles and limiting immune activation.

This study develops a zebrafish model of Zika virus infection and identifies NS4A as a key factor in neuropathogenesis through transcriptomic and morphological analyses.

This study identifies IGF2BP2 as a host factor hijacked by ZIKV to regulate viral replication organelle biogenesis and vRNA synthesis.