Shunmoogum A. Patten

This study shows that restoring calpastatin activity improves motor neuron function and survival in C9orf72 ALS models by enhancing synaptic proteolysis and NMJ integrity.

This study identifies conserved interactions of NS4B with the UFMylation pathway across orthoflaviviruses, revealing a novel role for UFMylation in viral replication and suggesting it as a therapeutic target.

This study develops a bilayered co-culture model of human mammary epithelial cells and shows that gap junction communication is essential for lineage-specific differentiation.

This study develops a zebrafish model of Zika virus infection and identifies NS4A as a key factor in neuropathogenesis through transcriptomic and morphological analyses.

This study investigates RFC1's role in zebrafish cerebellar development, showing its necessity for neural progenitor genomic integrity and neurogenesis.

This study identifies skeletal abnormalities in chd7-/- zebrafish, linking col2a1a depletion to craniofacial and spinal bone development defects in CHARGE syndrome.