Gianfranco Spalletta

The paper evaluates factors affecting brain-age prediction models using structural neuroimaging data from 35,683 individuals, finding optimal model performance with no site harmonization, age-binning, and a sample size of over 1,600.

This study investigates how structural brain alterations in schizophrenia relate to network architecture, finding hub susceptibility and shared epicenters across disease stages and disorders.

This study examines structural brain heterogeneity in schizophrenia using multimodal MRI data from the ENIGMA dataset, finding higher frontotemporal heterogeneity and left parahippocampal homogeneity in patients.

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

The paper identifies rare damaging variants in ATP8B4 and ABCA1 as novel risk factors for Alzheimer's Disease using exome sequencing data from 32,558 individuals.

This study finds that smaller ipsilesional hippocampal volume is associated with worse upper limb sensorimotor impairment in chronic stroke patients, with a stronger effect in women.

This study shows that global brain health, measured by brain age, influences post-stroke sensorimotor outcomes and mediates the effect of lesion damage.

This study finds that smaller spared subcortical nuclei are linked to worse sensorimotor outcomes after stroke, varying by time since stroke and type of impairment.

This study identifies white matter microstructural alterations in adult OCD patients and links them to clinical features, while finding no such abnormalities in pediatric patients.

The paper uses a novel gene-based analysis approach to identify three novel genes associated with Alzheimer’s disease using genome-wide association data.

The paper develops deep learning models to assess the quality of subcortical brain shape models from MRI, reducing human rater time by 46-70%.

This work uses machine learning to automate quality control of 3D brain shape models, reducing human workload by 30-70% across multiple datasets and diseases.