Author

Alexander C. Drohat

University of Maryland, BaltimoreORCID 0000-0002-7458-8770Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

B. D. FreudenthaliD· 1 shared Baiyu Zhu· 1 shared Bennett Van HouteniD· 1 shared Brittani L Schnable· 1 shared E. A. P. Tharaka Amarasekara· 1 shared Jérôme S. MenetiD· 1 shared Jonathan T. SczepanskiiD· 1 shared Lakshmi Swarna Mukhi PiduguiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

B. D. FreudenthalORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedFeb 26, 2026

Thymine DNA Glycosylase Binds to R-Loops and Excises 5-Formyl and 5-Carboxyl Cytosine from DNA/RNA Hybrids

Baiyu Zhu, Lakshmi Swarna Mukhi Pidugu, Mary E. Cook…·Jonathan T. Sczepanski

This study shows that TDG binds R-loops and removes 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids, supporting a role for R-loops in DNA demethylation.

2 citations

humanDNA methylation

𝕏 PostBluesky

BiophysicsNature CommunicationsPeer-reviewedOct 25, 2024

Single-molecule analysis reveals TDG exhibits multiple modes of linear diffusion to process 5-formylcytosine.

Brittani L Schnable, Matthew A. Schaich, Vera Y. Roginskaya…·Bennett Van Houten

This study uses single-molecule fluorescence to show TDG uses multiple diffusion modes to search for DNA lesions and how its structure affects nucleosome interactions.

20 citations

fluorescence / live-cell microscopyexperimental assay

𝕏 PostBluesky