Author
Alex A. Compton
National Cancer InstituteORCID 0000-0002-7508-4953Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2024-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 27 mutual co-author links5 papers
Recent·Most cited
- MicrobiologyJournal of VirologyPeer-reviewed
IFITM1 and IFITM3 cooperate to restrict virus entry in endolysosomes
Isaiah Wilt, Abigail A. Jolley, Kazi Rahman…·Alex A. Compton
This study shows that IFITM1 and IFITM3 work together to block virus entry in endolysosomes, with IFITM3 promoting IFITM1 localization to these compartments.
5 citationstop 2% - MicrobiologyScience AdvancesPeer-reviewed
Restriction of HIV-1 infectivity by interferon and IFITM3 is counteracted by Nef
Mahesh Agarwal, Kin Kui Lai, Isaiah Wilt…·Alex A. Compton
This study shows that HIV-1 Nef counteracts the antiviral effects of IFITM3 in interferon-treated cells by reducing its cell surface levels and impairing its function.
8 citations - MicrobiologyPLoS PathogensPeer-reviewed
Alternative splicing expands the antiviral IFITM repertoire in Chinese horseshoe bats
Nelly S. C. Mak, Jingyan Liu, Dan Zhang…·Richard D. Sloan
The paper identifies alternative splicing of IFITM genes in Chinese horseshoe bats, producing two isoforms with differential antiviral activities against influenza and coronaviruses.
9 citations - Cell BiologyThe EMBO JournalPeer-reviewed
SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion
Kazi Rahman, Isaiah Wilt, Abigail A. Jolley…·Alex A. Compton
The paper identifies a SNARE-like motif in the CD225 domain of IFITM3 that modulates SNARE complex assembly and endosomal fusion, revealing a mechanism for its antiviral activity.
12 citations