Ahmet Can Berkyurek

The paper identifies potent siRNAs against SARS-CoV-2 through RNAi screening, validates their efficacy against variants, and demonstrates their prophylactic potential in a hamster model.

The paper describes a scalable pipeline for constructing SARS-CoV-2 replicons using de-novo synthesis, demonstrating their safety and utility for drug testing.

This study identifies RPB-9 as essential for piRNA-mediated silencing in C. elegans by promoting transcriptional elongation/termination at piRNA loci.

The paper identifies the USTC complex as essential for piRNA transcription in C. elegans, revealing its role in genome defense through specific binding to piRNA clusters.

This study identifies the Aquarius/EMB-4 helicase as essential for initiating small RNA-induced co-transcriptional gene silencing in C. elegans by facilitating HRDE-1 complex engagement with nascent transcripts.