Benjamin S. Halligan

This study identifies four DENV inhibitors from a drug library using high-content screening and a pseudotime model to map drug mechanisms onto viral life cycle stages.

This paper uses patient-derived liver organoids and machine learning to identify hepatotoxic compounds by analyzing morphological changes, achieving high accuracy in distinguishing toxicants from non-toxicants.

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.