Samuel M. Young

The paper investigates the role of CaV2.1 calcium-dependent facilitation in auditory synaptic transmission, finding that its absence reduces synaptic reliability and precision.

The paper shows that pre-sensory spontaneous activity initiates and drives synaptic maturation but can be partially compensated for in its absence.

This study demonstrates that engineered tRNA can restore vision in a mouse model of Leber Congenital Amaurosis by suppressing a premature termination codon.

The paper investigates motifs in CaV2.1 subunits that regulate presynaptic abundance and preference, finding distinct motifs control abundance versus preference.

This study shows that presynaptic Rac1 regulates synaptic strength by controlling synaptic vesicle priming and release probability in mouse calyx of Held synapses.

The paper investigates the role of CAST/ELKS in presynaptic development, finding reduced surface area and increased active zone size but no impairment in synaptic transmission.

The paper measures mitochondrial volume changes in calyx of Held synapses during development and finds increased mitochondrial volumes from postnatal day 7 to 21.