Author
University of TorontoORCID 0000-0002-7601-4543Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Mélanie Uguen, Devan J. Shell, Madhushika Silva…·Stephen V. Frye
The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.
Suzanne Z. Ackloo, Fengling Li, Magda Szewczyk…·C. H. Arrowsmith
The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.
Dong Cheng, Yanli Liu, Tian‐Jie Lyu…·Jinrong Min
This study determines the structural basis for CDY chromodomain selectivity in binding lysine-methylated ARKS motifs, revealing distinct preferences for H3K9me3 and H3K27me3.