Dong Cheng

The paper identifies PANK1β and PANK3 as substrates of the Arg/N-degron pathway, revealing two distinct E3 ligase systems that regulate CoA biosynthesis through ubiquitin-dependent degradation.

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.

The paper develops chemical tools and probes for the Gid4 subunit of the human CTLH E3 ligase complex, achieving sub-100 nM binding affinity for further study.

This study shows PHF1 and PHF19 Tudor domains preferentially bind H3tK27me3 over canonical H3K27me3, revealing structural basis for their recognition.

This study determines the structural basis for CDY chromodomain selectivity in binding lysine-methylated ARKS motifs, revealing distinct preferences for H3K9me3 and H3K27me3.