BiochemistryCommunications BiologyPeer-reviewed
Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly
Jim Monistrol, Joseph G. Beton, Erin C Johnston…·Helen R. Saibil
This study shows DNAJB1 recruits Hsc70 in two steps to amyloid fibers, forming ordered arrays that enable efficient disaggregation, while a mutant disrupts this organization.