Cell BiologyMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewed
CRISPR screen for rAAV production implicates genes associated with infection
E. O'Driscoll, Sakshi Arora, Jonathan F. Lang…·Ophir Shalem
The paper uses a CRISPR screen to identify genes affecting rAAV production in HEK 293 cells, finding that heparan sulfate biosynthesis and vesicular trafficking genes influence yield.