Anouk Lkharrazi

The paper identifies IFI16 as a restriction factor for AAV2 transduction that acts independently of immune modulation by interfering with Sp1-dependent promoter activation.

The paper shows that inducing autophagy with hyperosmotic sucrose enhances AAV2 transduction efficiency through a non-canonical pathway, distinct from the PI3K-III-dependent mechanism.

This study compares AAV2 DNA replication mechanisms under HSV-1 and AdV5 helper virus conditions, finding that HSV-1 supports rolling circle replication while AdV5 supports rolling hairpin replication.

The paper investigates AAV2 uncoating and finds it occurs in a stepwise process completed in the nucleolus, with structural reorganization of the nucleolus supporting this process.