Luke E. Formosa

This study uses proximity labeling to identify proteins near the BAK pore during apoptosis, revealing SLC35A4-MP's role in modulating mitochondrial dynamics.

This study investigates the functional differences between MTX1 and MTX3, showing that their loss leads to distinct mitochondrial phenotypes and that both depend on MTX2 for stability.

This study shows that the AML chemotherapy regimen induces cachexia in mice, characterized by body and lean mass loss, and identifies haptoglobin as a potential biomarker for chemotherapy-induced cachexia.

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

This study uses untargeted proteomics to rapidly prioritize genetic variants in mitochondrial and other rare diseases, achieving functional evidence for 83% of cases in a cohort.

This study shows that estrogen loss in female mdx mice reduces exercise capacity and mitochondrial metabolism, but estrogen replacement therapy can reverse these effects and upregulate Rbm20.