Richard Peter Owen

This study shows that the order of FBXW7 and APC mutations affects colorectal cancer initiation, with FBXW7 mutations before APC preventing cancer-like features.

MOSES quantifies cellular motion phenotypes across different epithelial cell types and identifies boundary formation changes in response to external stimuli.

The paper uses single-cell RNA-seq to compare Barretts esophagus with normal esophageal tissues, finding transcriptional similarities with esophageal cells but not with gastric or duodenal cells.

BEARscc improves single-cell RNA-seq clustering by simulating technical replicates using RNA spike-ins to reduce technical variance.