John Dorrance Minna

This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.

The paper shows that the integrated stress response (ISR) coordinates the translation of PD-L1 and CD155, two immune checkpoint proteins, in lung cancer, and suggests combining ISR inhibition with PD-1 blockade as a therapeutic strategy.

This study shows that TMPRSS11B promotes an acidified and immunosuppressive tumor microenvironment in lung squamous cell carcinoma, suggesting it as a therapeutic target.

This paper develops a novel MICA/B-targeting antibody that enhances NK cell activity and shows therapeutic efficacy in KRAS LKB1 mutant lung cancer models.

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

This study compares neuroendocrine (NE) features in SCLC and NBL, finding similar molecular profiles and shared therapeutic responses but no significant survival association with NE scores.

This paper establishes reference standards for mosaic variant analysis using a large set of simulated variants to improve detection accuracy and algorithm development.

The paper analyzes single-cell RNA-seq data to identify ACE2 expression patterns in human lung epithelial cells, finding high ACE2 expression in alveolar type II cells and co-expression with pathogen receptors.

The paper develops a deep learning tool to analyze pathology images and identify TME features predictive of survival in lung cancer.

The paper infers protein kinase pathways in lung adenocarcinoma using phosphotyrosine data and validates them with SILAC assays, revealing novel substrates and synergistic drug responses.