Boram Lee

This study develops a method to generate human anterior neural organoids (hANOs) and uses them to model microcephaly in Cohen syndrome by analyzing gene expression and cellular phenotypes.

This study uses high-resolution spatial transcriptomics to analyze breast cancer and its microenvironment, revealing spatially distinct immune cell gradients and transcriptional differences between tumors.

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

JuLI improves DNA fusion detection in clinical sequencing by reducing false positives and increasing sensitivity, outperforming existing methods in high-depth sequencing.