Craig J. Bierle

This study uses Pichinde virus to model arenavirus infection during pregnancy, showing placental infection and fetal demise while highlighting antiviral responses.

This study uses spatial transcriptomics to show that GPCMV infection disrupts placental function by altering chemokine signaling and antiviral defense in specific regions.

This study evaluates two replication-deficient whole-virus vaccines against GPCMV in a guinea pig model, showing they are attenuated and provide protective immunity against maternal viremia and congenital infection.

This study shows CD4+ T cells are critical for preventing severe congenital cytomegalovirus infection in guinea pigs, while CD8+ T cell depletion increases placental viral load without affecting disease severity.

This study shows that human trophoblast stem cells restrict HCMV replication but alter gene expression related to differentiation and cell fate, potentially impairing placental function.