Haodi Wu

WHaloForce is a chemigenetic tension sensor that images molecular forces in living cells and animals, revealing tissue-specific force patterns and ovulation-related molecular loading.

The paper develops mRNAbow, a system for generating low-toxicity mRNAs for multiplexed fluorescent imaging in diverse cellular and organismal systems.

The paper develops a 2D/3D hybrid organoid system for high-throughput drug screening in iPSC cardiomyocytes, validated using doxorubicin to assess cardiotoxicity and electrophysiological effects.

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

This study investigates how the PLN R9C mutation affects iPSC-CMs and shows that promoting autophagy can mitigate stress-induced structural and functional defects in these cells.

This study shows that tyrosine kinase inhibitors cause mitochondrial dysfunction in cardiomyocytes by altering GATA4-mediated networks, and GATA4 overexpression can rescue these effects.