PhysiologyScience SignalingPeer-reviewed
Vasodilators activate TMEM16A channels in endothelial cells to reduce blood pressure
Alejandro Mata‐Daboin, Tessa A. C. Garrud, Carlos Fernández‐Peña…·Jonathan H. Jaggar
Vasodilators stimulate TRPV4 channels, leading to calcium-dependent activation of nearby TMEM16A channels in endothelial cells to produce arterial hyperpolarization, vasodilation, and reduced blood pressure.
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