Helen Eachus

This study investigates the lifelong molecular effects of high glucocorticoid exposure during development using a zebrafish model, identifying GC-primed genes and epigenetic changes linked to psychiatric disorder risk factors.

This study shows that elevated glucocorticoid exposure during zebrafish development disrupts hypothalamic neurogenesis, leading to developmental abnormalities and reduced survival.

This study uses optogenetics to chronically activate glucocorticoid signaling in larval zebrafish, showing impaired stress response and reduced POMC-expressing cells.

This study identifies two distinct GR-regulated transcription pathways in zebrafish brains, showing synaptic activity's role in GR-mediated transcription of aplp1.