William J. Comstock

This paper introduces ProKAS, a proteomic platform for spatial and quantitative analysis of kinase activity using mass spectrometry, and demonstrates its application in studying DNA damage response kinases.

The paper identifies a novel phosphorylation motif in Tel1 signaling that expands the understanding of its role in DNA repair and telomere control.

MAGMa is a tool for differential expression analysis in mass-spectrometry proteomic data, showing improved sensitivity and specificity in detecting true signals.

This study identifies a distinct Mec1/ATR signaling mode triggered by DNA end hyper-resection, showing its role in regulating HR-mediated DNA repair through phosphorylation of the STR complex.

This paper develops a quantitative phosphoproteomic approach to improve reliability and reduce false positives in kinase signaling network analysis, expanding the Mec1 and Tel1 networks.