Santiago Solé‐Domènech

The paper uses ApHID-dextran to measure lysosomal pH in mouse meningeal phagocytes, revealing incomplete acidification and changes under pathological conditions.

This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.

The paper introduces a novel pH-sensitive probe, ApHID, for real-time ratiometric pH imaging of macrophage lysosomes, showing improved performance over existing probes.