Mir‐Farzin Mashreghi

This study shows that TLR activation in OA synovial fibroblasts leads to inflammatory responses and chondrocyte dysfunction.

The paper identifies NK cells as key orchestrators of adaptive immune niches in early arthritis by upregulating XCL1, which recruits XCR1+ cDC1s, forming pathogenic modules that correlate with disease severity.

This paper develops gene-edited tacrolimus-resistant Treg cells (FKBP12KO-Treg) for clinical use in transplant recipients, showing they maintain immunoregulatory function while resisting tacrolimus.

This study identifies tissue-specific signaling pathways critical for memory T cell persistence in spleen and bone marrow.

The paper examines T-bet expression stability in virus-specific Th1 cells during chronic infection, finding that quantitative differences persist and some cells retain Tfh-like features.

This study uses single-cell RNA-seq to profile seasonal changes in Plasmodium falciparum parasites, showing older parasites circulate in the dry season and transcriptional changes in exported proteins affecting cytoadhesion.

This study identifies D-lactate's stereospecific role in enhancing Th1 cell cytotoxicity and inflammation through mitochondrial ROS regulation.

The paper identifies and characterizes three subsets of human CD8+ regulatory T cells using single-cell CITE-seq and VDJ sequencing, highlighting a subset with superior suppressive activity.

This study uses urinary single-cell RNA sequencing to analyze injury and repair processes in acute kidney injury, identifying distinct cellular and molecular dynamics.

This study combines bulk and single-cell RNA-seq to identify chondrocyte gene expression in murine knee joints, finding 75 overlapping genes related to cartilage homeostasis and osteoarthritis.