Frederik Heinrich

This study shows that TLR activation in OA synovial fibroblasts leads to inflammatory responses and chondrocyte dysfunction.

This paper develops gene-edited tacrolimus-resistant Treg cells (FKBP12KO-Treg) for clinical use in transplant recipients, showing they maintain immunoregulatory function while resisting tacrolimus.

This study identifies tissue-specific signaling pathways critical for memory T cell persistence in spleen and bone marrow.

The paper identifies and characterizes three subsets of human CD8+ regulatory T cells using single-cell CITE-seq and VDJ sequencing, highlighting a subset with superior suppressive activity.

This study combines bulk and single-cell RNA-seq to identify chondrocyte gene expression in murine knee joints, finding 75 overlapping genes related to cartilage homeostasis and osteoarthritis.