Léa Flippe

The study shows that RUNX1-ETO levels determine endothelial reprogramming and hematopoietic cell growth in AML by altering the balance between these processes.

This study identifies heme biosynthesis as a selective dependency in AML, showing that its inhibition triggers cuproptosis via copper accumulation and reveals synthetic lethal pathways for therapeutic strategies.

The paper identifies and characterizes three subsets of human CD8+ regulatory T cells using single-cell CITE-seq and VDJ sequencing, highlighting a subset with superior suppressive activity.

This study generates T-cell progenitors from human pluripotent stem cells to produce functional thymocytes, demonstrating similarity to cord blood HSCs and DN3a thymocytes.