Andrey G. Baranovskiy

This study determines the cryo-EM structures of HSV-1 helicase-primase complex with and without inhibitors, revealing how pritelivir and amenamevir block helicase activity.

This study shows RPA is critical for human primosome DNA synthesis across inverted repeats, with a specific winged helix-turn-helix domain enhancing RPA-Pol cooperation and structural integration.

This study shows Nsp1 inhibits DNA synthesis at hairpin-forming inverted repeats by competing with RPA's wHTH domain on Pol, with a lower IC50 than wHTH.

The paper identifies a PrimPol variant V102A with reduced primase and polymerase activities linked to ovarian and cervical cancer.

This study shows RPA binds RNA and promotes R-loop formation, suggesting a role in RNA metabolism and genome maintenance.