Author

Marjolein M. E. Isendoorn

Leiden UniversityORCID 0000-0002-8076-3766Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Dmitri V. FilippoviD· 1 shared Douwe J. DijkstraiD· 1 shared Dylan P. NooneiD· 1 shared Jip WulffeléiD· 1 shared Leendert Adrianus TrouwiD· 1 shared Mariska E. Keizer· 1 shared Sebastiaan M. W. R. HamersiD· 1 shared Thomas Harry SharpiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

Dmitri V. FilippovORCID

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1 paper

Recent·Most cited

ImmunologyProceedings of the National Academy of SciencesPeer-reviewedSep 6, 2024

Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein

Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers…·Thomas Harry Sharp

This paper presents a cryo-ET structure of CRP bound to C1 complex and PC ligands, revealing how CRP activates complement and identifies residues for therapeutic targeting.

31 citationstop 4%

humancryo-EM

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