Milena Simovic-Lorenz

This study integrates spatial and multi-omic data from bladder cancer patients to show L1 retrotransposition drives genomic instability, ecDNA formation, and a viral mimicry response.

HIPSD&R-seq profiles genomic copy number and transcriptomes in thousands of cells, enabling rare clone detection in human cell models and primary tissue.

This paper introduces a method to generate localized DNA double-strand breaks in cell populations using UV-irradiation with photomasks, enabling the study of genome rearrangements and DNA damage response.