Kara Rainbow

The paper creates a spatio-cellular map of the mouse nodose ganglia using single nucleus RNA sequencing and spatial transcriptomics, revealing subtype-specific gene expression and spatial organization.

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.

The paper presents HYPOMAP, a comprehensive spatio-cellular map of the human hypothalamus, identifying BMI-associated genes and potential druggable targets.

This study identifies fetal and maternal GDF15 as key factors in pregnancy-related nausea and vomiting, showing their roles in disease risk and severity.

The paper identifies the prevalence and phenotypic impact of loss of function mutations in the MC4R gene in a UK birth cohort, finding a 0.30% carrier rate with significant effects on body weight and BMI.

The paper shows that transcription starts much earlier in mouse and human one-cell embryos than previously thought, driven mainly by the maternal genome.