Orna Dahan

The paper identifies the syntax of SECReTE, a secretion-enhancing cis regulatory element, through a parallel reporter screen in mammalian cells, revealing key sequence patterns and their impact on mRNA localization and protein secretion.

This study investigates the evolution of gene regulation in trypanosomatids, showing a shift from gene-specific regulation to architecture-encoded regulation through polycistronic transcription units.

This study examines how HCMV and SARS-CoV-2 affect the human tRNA pool and finds HCMV alters tRNA expression and modifications, while SARS-CoV-2 does not, with implications for viral codon usage and host-virus interactions.

This study investigates the evolutionary origins of host association and polycistronic transcription in trypanosomatids using comparative genomics across 47 genomes.

The paper identifies and characterizes non-genetic and genetic protein variants in human proteomes, showing they contribute to functional diversity.

This study quantifies mating affinity among natural Saccharomyces cerevisiae strains and finds that adaptive mating preferences enhance hybrid fitness.

The paper analyzes hybrid fitness in S. cerevisiae strains under different carbon sources, finding correlations with parental fitness and genetic distance.

The paper examines dynamic changes in tRNA modifications and abundance during T-cell activation, finding reduced wybutosine and ms2t6A modifications that may increase ribosomal frameshifting and facilitate HIV infection.

The paper investigates how intronic sequence features influence splicing efficiency and mRNA expression in yeast, revealing evolutionary adaptations and mechanisms of alternative splicing.

The paper identifies tRNA subsets essential for cellular proliferation or arrest by CRISPR-based editing and functional analysis in human cell lines.

The paper systematically detects amino acid substitutions in proteomes using mass spectrometry data and reveals that translation errors are primarily caused by codon-anticodon mispairing, with patterns influenced by ribosome velocity and evolutionary constraints.