Michal Schwartz

This study examines how HCMV and SARS-CoV-2 affect the human tRNA pool and finds HCMV alters tRNA expression and modifications, while SARS-CoV-2 does not, with implications for viral codon usage and host-virus interactions.

This study shows that reduced viral entry in monocytes leads to HCMV latency, while efficient entry enables productive infection, highlighting entry as a key determinant of latency.

The paper shows that systemic PD-L1 blockade removes senescent microglia in mice, reducing neuroinflammation and suggesting a therapeutic role in Alzheimer's disease.

This study identifies impaired bone marrow myelopoiesis in Alzheimer's disease, driven by type I interferon signaling, and shows that targeting this pathway improves myeloid function and cognitive outcomes.

A single anti-PD-L1 injection reduces tau pathology and cognitive deficits in P301S mice but the effect is transient.

This study shows that overexpression of HCMV IE1 or IE2 enhances productive infection, with IE2 driving early gene expression and IE1 disrupting PML nuclear bodies to promote lytic infection.

This study develops VECOS, a viral-encoded CRISPR screen to analyze host dependencies during cytomegalovirus infection, identifying novel factors and revealing the importance of virion assembly.