Xu Zhang

This study uses atomic-level simulations to show how ligand binding modulates conformational dynamics of the M2 muscarinic receptor, revealing key aromatic residue interactions involved in activation.

The paper shows MyoD organizes 3D genome architecture in muscle cells and demonstrates H3K27ac is insufficient for MyoD-induced chromatin loops.

This paper introduces Tn5-FISH, a method to visualize chromatin interactions at sub-kilobase resolution and validate results from 3C-derivative methods.