Griffin I. Kane

This study shows ADAMTS9 deletion in mice causes polycystic kidney disease by disrupting ciliogenesis and collagen homeostasis, leading to small, cystic kidneys and early lethality in males.

This study shows that delivering multiple cytokine and antigen mRNAs via nanoparticles can generate strong anti-tumor immunity against pancreatic cancer in mice.

This paper combines nanoparticle-delivered immune agonists with senescence-inducing agents to enhance T cell responses and control pancreatic cancer in preclinical models.