Guy‐Franck Richard

The paper shows that CTG trinucleotide repeats form imperfect hairpin structures in living cells, specifically as heteroduplex DNA molecules.

This study uses TALENs to contract CTG repeats in DM1 cells, achieving 68% contraction with a recoded TALEN, while SaCas9 failed, and identifies potential off-target effects.

The paper investigates the functional roles of megasatellites in yeast adhesion and flocculation by deleting genes and evolving strains.

The paper evaluates the efficacy of CRISPR-Cas nucleases on microsatellites linked to human disorders, identifying variations in cleavage efficiency and off-target mutations.

This study shows that using Cas9 to induce a double-strand break at CTG trinucleotide repeats leads to chromosomal rearrangements, highlighting risks of using Cas9 near microsatellites.