Dupaigne Pauline

This study identifies and characterizes P-motifs in BRCA2 and RAD54B that bind to DMC1 filaments through stable and transient interactions, revealing structural insights into their roles in meiotic recombination.

The paper shows that the RecBC complex protects nascent DNA from degradation by ExoI during lesion bypass, ensuring efficient repair of single-stranded DNA gaps.

The paper identifies a non-canonical BRCA2 variant in moss that promotes homologous recombination and binds ssDNA without a canonical DNA binding domain.

The paper shows that CTG trinucleotide repeats form imperfect hairpin structures in living cells, specifically as heteroduplex DNA molecules.

This paper explains how BRCA2's FxxA and FxPP motifs bind to DMC1 and RAD51 via distinct interfaces, stabilizing recombinase filaments and explaining functional differences between these proteins.

This study identifies the FIGNL1-FIRRM complex as essential for completing meiotic recombination in mice by regulating RAD51 and DMC1 loading, independent of DNA damage.

This study uses electron microscopy to analyze replication intermediates in UV-irradiated human cells, revealing the role of pol{eta} and RAD51 in DNA damage tolerance mechanisms.

This study shows RAD51 inhibits non-conservative DNA repair pathways by blocking ssDNA annealing, independent of its catalytic activity.