Tao Xu

The paper develops a CSF proteomic aging clock that predicts age and disease progression, identifying opposing aging programs associated with neurological disorders.

This study identifies HGS-enlarged vesicular compartments as sites of coronavirus virion assembly at later infection stages using multiple imaging techniques.

This study identifies PKM1-regulated PEP metabolism as a key factor in improving functional maturation of human stem-cell derived β cells by enhancing calcium response and insulin secretion.

This study identifies HGS as a host factor critical for coronavirus infection and discovers RTB as a broad-spectrum antiviral by disrupting HGS-M protein interaction.

This study analyzes mitochondrial DNA variants and nuclear mitochondrial DNA segments in 7331 individuals from NyuWa and 1KGP, identifying common and ultra-rare NUMTs and linking mtDNA variants to nuclear DNA variants.

The paper identifies a stress granule-driven necroptosis pathway involving ZBP1 and RIPK3 as a driver of non-obstructive azoospermia and age-related testicular degeneration.

The paper investigates HLA allele adaptation to pathogens and its correlation with autoimmune diseases in Han Chinese individuals, identifying specific alleles linked to both pathogen resistance and disease susceptibility.

The paper presents the NyuWa genome resource, a Chinese population-specific reference panel built from deep whole genome sequencing, which improves imputation accuracy and identifies novel variants.

The paper reports a comprehensive map of 36,699 non-reference mobile element insertions (MEIs) from 5,675 human genomes and builds a database for public use.

This study shows that necroptosis in testes accelerates aging of the male reproductive system in mice by promoting cellular deterioration.