Joseph Santos‐Sacchi

The paper uses electrophysiological recordings to study exocytic properties of zebrafish lateral line hair cells during development, finding no positional variation but reduced capacitance in tail-region cells and a role for otoferlin b.

This study shows that prestin's conformational changes during electromechanical transduction resemble a transport transition in pendrin, with shared structural and functional properties.

This study shows that knocking out alpha2 spectrin in postnatal outer hair cells leads to a dissociation of prestin's gating charge movement from electromotility and structural changes in the SSC and plasma membrane-SSC space.

This study shows chloride binding does not affect very high-frequency nonlinear capacitance in mouse outer hair cells, suggesting mechanical loads, not anion interactions, govern high-frequency prestin function.

The paper investigates the role of the PXDLS/T-binding cleft in Ribeye's function at synaptic ribbons, showing that mutations in this region impair ribbon structure and synaptic transmission in zebrafish.

This paper presents the single particle cryo-EM structure of prestin from gerbil at 4.0 Å resolution, revealing its dimeric architecture and structural features that challenge the extrinsic voltage sensor hypothesis.

This study shows that βV spectrin knockout mice have normal outer hair cell function but reduced auditory brainstem response amplitudes and fewer nerve fibers, indicating βV spectrin's role in neuronal structure rather than OHC function.

This study shows that the MOC efferent system couples bilateral spontaneous activity in the developing auditory system, and its absence reduces auditory sensitivity at hearing onset.