Deyin Guo

LucaPhylo infers phylogenetic trees from unaligned protein sequences using hyperbolic geometry and protein language models, achieving accuracy comparable to alignment-based methods for divergent RNA viruses.

SegFinder identifies RNA virus genome segments by analyzing co-occurrence across samples, discovering novel segments and expanding known segmented virus families.

The paper analyzes wildlife infectomes to identify zoonotic pathogens, finding 62 novel pathogens including a new coronavirus genus and highlighting high pathogen diversity in Carnivora and Rodentia.

The paper identifies 162 viral species in small mammals from Yunnan, China, including 102 novel species and 24 with potential human health risks.

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

VirID improves RNA virus discovery and characterization from metagenomic data by reducing false positives, accurately estimating diversity, and identifying virus-host associations.

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.