Pierre J.J. Mangeol

The paper applies spatial transcriptomics to the adult Drosophila brain and body to map mRNA locations and integrate with single-cell data.

The paper identifies a titin-dependent biomechanical feedback mechanism that adjusts sarcomere structure to meet the functional demands of different insect muscle types.

This study identifies Tono as a mechanically responsive transcriptional regulator that controls sarcomere maturation through liquid-liquid phase separation in Drosophila muscle development.

PatternJ is an ImageJ toolset for automated quantitative analysis of regular spatial patterns in biological structures, validated on diverse imaging data.

The paper develops a nanobody toolbox to study the localization and dynamics of Drosophila titin homologs in muscle sarcomeres, revealing structural insights and demonstrating nanobodies' utility in vivo.

The paper uses nanobodies and DNA-PAINT to show that Drosophila titin homologs Sallimus and Projectin are staggered in flight muscle sarcomeres.