Alec A. Desai

This study develops HALA antibodies that adjust ADC delivery based on tumor HER2 expression, improving efficacy across varying expression levels in preclinical models.

This paper describes a method to generate biepitopic antibodies that activate TNF receptors by combining single-chain antibodies with IgG light chains, enhancing agonist activity without animal immunization.

The paper identifies a high-homology light chain sequence from a hybridoma that is antigen-specific, highlighting challenges in variable domain sequencing.