ImmunologybioRxiv
RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppression
Augusto Bleve, Martina Incerti, Francesca Maria Consonni…·Antonio Sica
This study shows RORγ mediates cancer-driven lipid dysmetabolism and myeloid immunosuppression by promoting MDSC expansion and M2 TAM polarization, with cholesterol lowering reversing these effects.
DOI 10.1158/2159-8290.cd-24-0199