João Rodrigues Lima-Júnior

This study shows that knocking down the long isoform of the prolactin receptor reduces pathogenic immune cells and prevents lupus nephritis in SLE-prone mice.

The paper measures ligand discrimination errors and molecular noise in immune cells of ER+ breast cancer patients compared to healthy controls using a communication model.

The paper shows that lymphocytes and monocytes suppress IL-10R, IL-6R, and IL-2Rβγ signaling under high cytokine concentrations, mediated by cytokines that do not induce their own pSTATs.

The paper identifies PINK1 as an autoantigen targeted by T cells in Parkinson's disease, with reactivity predominantly observed in male patients.

The paper profiles cytokine signaling responses in breast cancer patients and finds coordinated dysregulation across pathways and cell types, suggesting immune cell reprogramming and immunosuppression.